AUGS/IUGA Scientific Meeting 2019-Basic Science Lecture - Stem Cells and Scaffolds for POP: Designing the Future

Basic Science Lecture - Stem Cells and Scaffolds for POP: Designing the Future

Video Transcription

Video Summary

The speaker discusses their work on mesenchymal stem cells (MSCs) and scaffolds in the context of prolapse. They explain that MSCs can be sourced from various tissues, including bone marrow, adipose tissue, umbilical cord, placenta, and endometrium. The focus is on using MSCs from the endometrium, as this tissue is highly regenerative. The speaker describes the characterization of these MSCs and the identification of specific surface markers. They also discuss the development of culture expansion protocols to keep the cells undifferentiated and the use of a small molecule screen to maintain their undifferentiated state. The speaker highlights the importance of standardized release criteria when using MSCs for autologous treatments. They then discuss the development of different biomaterials for prolapse repair, including a non-degradable polyamide mesh and degradable electrospun nanofibers. The speaker presents data from animal models to demonstrate the efficacy of these materials in promoting tissue repair. They also mention ongoing work on 3D printing and bioprinting of MSCs. The video concludes with acknowledgments and a Q&A session.

Asset Caption

Caroline Gargett, PhD

Keywords

mesenchymal stem cells

prolapse

endometrium

biomaterials

tissue repair

3D printing