AUGS/IUGA Scientific Meeting 2019-Long Oral Session 1

Video Transcription

Video Summary

Dr. Oksana presented on the challenges and breakthroughs in basic science research on female pelvic floor disorders. She discussed the prevalence of pelvic floor disorders and the need for better treatment options. One option that has gained interest is stem cell therapy, which can treat degenerative diseases and injuries. Dr. Oksana highlighted the need to choose the right cell type for therapy, such as mesenchymal stem cells, adipose-derived cells, or muscle-derived cells. She also discussed the importance of selecting a suitable animal model for studying pelvic floor disorders, including small animal models like rodents and rabbits, as well as larger animal models like pigs, dogs, and non-human primates. Dr. Oksana focused on the use of urine-derived cells, which can be obtained less invasively and can be transformed into pluripotent stem cells for differentiation into various cell types needed for pelvic floor repair. She presented her research on transforming urine-derived cells into fibroblasts and skeletal muscle cells, as well as injecting these cells into immunocompromised rats, showing their presence in the periurethral area. Overall, Dr. Oksana's presentation highlighted the potential of stem cell therapy for improving the treatment of female pelvic floor disorders.

Asset Caption

Amanda M. Artsen, MD, Pamela Duran, BS, Indira U. Mysorekar, PhD, Luyun Chen, PhD, Heather van Raalte, MD, Bing Xie, MD, Oksana Shynlova, PhD

Keywords

female pelvic floor disorders

stem cell therapy

cell type

animal model

urine-derived cells

pluripotent stem cells

pelvic floor repair

fibroblasts

skeletal muscle cells