AUGS/IUGA Scientific Meeting 2019-Panel: Under the Microscope: Aetiology of OAB

Video Transcription

Video Summary

The video is a presentation about the relationship between the immune system and bacteria in the context of overactive bladder (OAB). The presenter discusses the barriers in the body that normally keep bacteria away from the immune system, such as the skin and vaginal epithelium, as well as the immune system's response when bacteria get past these barriers. The immune system is divided into two parts, innate immunity and adaptive immunity. Innate immunity is responsible for the tissue reaction that causes inflammation and pain, while adaptive immunity involves antibodies that clear up infections.<br /><br />The presenter then explains how cytokines, which are inflammatory chemicals, are related to OAB. There have been studies showing increased levels of cytokines in OAB, and these chemicals are released when cells are damaged. The presenter also discusses the role of mast cells, which can alter sensory function and contribute to inflammation and pain. Additionally, the presenter mentions the potential role of a urinary microbiome in OAB, as studies have shown differences in bacterial communities between individuals with OAB and controls.<br /><br />In conclusion, OAB is associated with bladder inflammation and increased levels of cytokines. There may also be abnormalities in the immune system and the presence of a urinary microbiome in individuals with OAB. Further research is needed to understand the mechanisms underlying these relationships and the potential microbial etiology of OAB.

Asset Caption

Rufus Cartwright, MD, PhD, MRCOG

Keywords

immune system

bacteria

overactive bladder

innate immunity

adaptive immunity

cytokines

mast cells

urinary microbiome