AUGS/IUGA Scientific Meeting 2019-Short Oral Session 1

Video Transcription

Video Summary

The video discusses various aspects of treating recurrent urinary tract infections (UTIs) and the potential use of fecal microbiota transplantation (FMT) as a treatment option. The presenter highlights the fact that the gastrointestinal tract can harbor uropathogenic E. coli, and that FMT has been shown to temporarily change the GI tract microbiota and decrease the occurrence of UTIs. The objective of the study presented was to determine the safety and efficacy of FMT via retention enema for women with refractory recurrent UTIs. The study involved 11 participants who received FMT, with no significant adverse outcomes reported. The study found a significant reduction in the number of UTIs per participant from six months prior to FMT to six months post-FMT. It also observed a decrease in the presence of multidrug-resistant organisms after FMT. The participants rated their improvement in UTI symptoms and microbial analysis showed changes in the composition of the fecal microbiota post-FMT. The presenter concludes that FMT via retention enema is a safe and well-tolerated procedure for women with refractory recurrent UTIs. However, more randomized studies are needed to determine optimal administration methods and mechanisms of action.

Asset Caption

Yuanyuan Jia, PhD, Ahmad O. Khalifa, MD, PhD, Aparna S. Ramaseshan, MD, Salwan Al-Salihi, Sarah E. Steele, MD, Kshipra Hemal, BS, Melissa Kaufman, MD, PhD

Keywords

recurrent urinary tract infections

fecal microbiota transplantation

treatment option

gastrointestinal tract

uropathogenic E. coli

safety and efficacy

retention enema

refractory recurrent UTIs

multidrug-resistant organisms