E-Posters-10014_Amirahmadi

10014_Amirahmadi
Pdf Summary
A study conducted by Allen-Brady et. al. in 2011 found six SNPs associated with women at high risk of pelvic organ prolapse (POP) in Holland and Utah populations. The study aims to determine if the frequencies of these SNPs differentiate women with retroverted uteri from those with anteverted uteri. DNA was extracted from buccal swab samples of 35 women, and the uterus orientations were confirmed by physical exam and/or ultrasound. DNA sequencing was performed to analyze the SNPs of interest. Retroverted uteri, which are anatomically positioned differently than anteverted uteri, have been linked to an increased risk of developing POP. The study found that the frequencies of these POP-associated SNP alleles did not differ significantly between the retroverted and anteverted groups for most loci. However, in one locus, the frequencies of the minor allele were different. This suggests that genetic determinants for POP and retroverted uterus orientation overlap but not in all expected SNP subsets. Further research is needed to determine allele frequencies among larger populations and identify additional genomic variations associated with retroverted uterus and its co-morbidities. The study also suggests that some women with retroverted uterus may be less predisposed to developing prolapse, and additional factors may influence the development of collagen in the uterosacral ligament. The findings highlight the potential for precision medicine in identifying individuals with retroverted uteri who are less likely to develop clinical symptoms.
Keywords
study
Allen-Brady
SNPs
women
pelvic organ prolapse
Holland
Utah
retroverted uteri
anteverted uteri
DNA sequencing