E-Posters-10025

10025_Chong

Pdf Summary

This study aimed to investigate the expression of β3-adrenoceptor (β3-AR) in the uterosacral ligaments (USLs) of postmenopausal women with pelvic organ prolapse (POP). Ten subjects were recruited, and a piece of distal USL was collected for histologic evaluation. The average POP quantification (POPQ) was stage 3, and four out of nine subjects reported urinary symptoms, including overactive bladder (OAB). On H&E staining, the USL specimens were composed of smooth muscle cells (SM cells) and connective tissues. Immunohistochemistry (IHC) analysis revealed β3-AR expression in six out of the nine specimens, with varying levels of expression. Two specimens expressed low amounts of β3-AR, one had intermediate expression, and three had high expression. <br /><br />The presence of β3-AR in the USLs is significant as they are thought to contribute to pelvic floor support. The effect of β3-AR agonist on pelvic floor tissues should be investigated further, considering the frequent occurrence of both POP and OAB in the elderly population. This study provides preliminary evidence of β3-AR expression in the USLs of postmenopausal women with POP.<br /><br />Overall, this study highlights the importance of understanding the expression of β3-AR in pelvic floor tissues and its potential implications for the treatment of POP and OAB. Further research is needed to explore the effects of β3-AR agonists on the pelvic floor and its potential therapeutic benefits in this population.

Keywords

β3-adrenoceptor

β3-AR

uterosacral ligaments

postmenopausal women

pelvic organ prolapse

urinary symptoms

overactive bladder

smooth muscle cells

immunohistochemistry

pelvic floor support