E-Posters-10049_Willis

10049_Willis_Gray
Pdf Summary
This study aimed to compare the amount of lidocaine administered in women undergoing vaginal reconstruction with and without hysterectomy, and to assess the risk of lidocaine toxicity and associated complications. Lidocaine is a local anesthetic used in pelvic reconstructive surgery with analgesic and anti-inflammatory properties. However, lidocaine toxicity can occur and lead to CNS and cardiovascular disorders. The study found that there have been no previous studies on the risk of lidocaine toxicity in women undergoing pelvic reconstructive surgery.<br /><br />The researchers conducted a retrospective cohort study comparing lidocaine dose in two groups: vaginal hysterectomy with additional vaginal reconstruction (VH+VR) and vaginal reconstruction without hysterectomy (VR-only). The primary outcome measured was the total amount of intraoperative lidocaine administered by the anesthesia and surgical teams. The secondary outcome was the risk of lidocaine toxicity, defined as a total dose greater than 7 milligrams/kilograms (mg/kg).<br /><br />The results showed that women undergoing VH+VR were more likely to receive a higher dose of lidocaine compared to women undergoing VR-only. In a linear regression model, vaginal hysterectomy remained an independent risk factor for increased lidocaine dose, as did anesthesia type, sling, and posterior repair. The risk of lidocaine toxicity was low but increased with the number of concomitant procedures.<br /><br />The study also presented demographic data, showing similar mean age and BMI between the two groups. However, there were significant differences in race, with more Caucasian women in the VR-only group. Advanced pelvic organ prolapse was more prevalent in the VH+VR group. Anesthesia type, estimated blood loss, and days in the hospital were also significantly different between the groups.<br /><br />In conclusion, this study found that women undergoing vaginal hysterectomy with additional vaginal reconstruction were more likely to receive a higher dose of lidocaine. The risk of lidocaine toxicity was low but increased with the number of concomitant procedures. These findings highlight the importance of considering lidocaine dose and potential toxicity in urogynecologic surgery.
Keywords
lidocaine
vaginal reconstruction
hysterectomy
lidocaine toxicity
complications
pelvic reconstructive surgery
retrospective cohort study
anesthesia type
concomitant procedures
urogynecologic surgery