E-Posters-10064

10064_Price

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The study aimed to investigate the differences in the Female Urinary Microbiota (FUM) in women with lower urinary tract disorders compared to women without symptoms. The researchers collected urine samples from 384 adult women, categorized into four groups: those with urinary tract infection (UTI), urgency urinary incontinence (UUI), stress urinary incontinence (SUI), and those without lower urinary tract symptoms (non-LUTS). The bacterial growth in the samples was assessed using an enhanced quantitative urine culture (EQUC) protocol. The results showed variations in the dominant genera of bacteria among the different cohorts. Genera containing typical pathogens were enriched in the UTI cohort, while other genera were enriched in the non-LUTS, SUI, and UUI cohorts. The non-LUTS cohort tended to be culture-negative or dominated by Lactobacillus, while Escherichia dominated the UTI cohort. The UUI and SUI cohorts had similar compositions and differed from the non-LUTS cohort mainly in the percentage of mixed cultures, indicating lower diversity in the non-LUTS cohort. The study concluded that the FUM differs in the presence of lower urinary tract symptoms (LUTS) and that the primary LUTS disorders are associated with differences in FUM composition. The study also identified Aerococcus as an emerging uropathogen. The results highlight the importance of studying the urinary microbiota in relation to lower urinary tract disorders and provide insights into potential microbial differences among different disorders and non-symptomatic individuals.

Keywords

Female Urinary Microbiota

lower urinary tract disorders

urinary tract infection

urgency urinary incontinence

stress urinary incontinence

lower urinary tract symptoms

bacterial growth

diversity

Aerococcus

uropathogen