E-Posters-10100

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This study aimed to compare the male urinary microbiota (MUM) to the female urinary microbiota (FUM) in patients with and without lower urinary tract symptoms (LUTS). Urine is not sterile and contains bacterial DNA that can be amplified and bacterial isolates that can be cultured. The composition of the female urinary microbiota differs between those with and without urgency urinary incontinence (UUI). The MUM was examined in 37 adult men, categorized into 21 with benign prostatic hyperplasia (BPH)/LUTS and 16 without BPH/LUTS. Bacterial growth was assessed using Enhanced Quantitative Urine Culture (EQUC), and the bacteria were identified using Mass Spectrometry. <br /><br />The results showed that 48% of patients with BPH had detectable bacterial growth while only 13% of the non-BPH group had bacterial growth. The frequency of growth in the FUM was higher overall. Symptomatic patients had a higher rate of positivity in both male and female cohorts. The non-BPH patients with bacterial growth had dominant genera, Gardnerella and Staphylococcus, which are common in the female non-LUTS cohort. The female overactive bladder (OAB) cohort had a higher percentage of samples with mixed genera compared to the BPH cohort. All male patients had an absence of Lactobacillus, which is common in women.<br /><br />In conclusion, the MUM exists, but the bladders of men with and without BPH/LUTS appear to be EQUC negative more often than their female counterparts. Men with BPH/LUTS are more likely to have detectable bacterial growth, similar to women with symptoms. These findings suggest that the MUM may play a role in lower urinary tract pathology, similar to the impact of the FUM on female patients.

Keywords

male urinary microbiota

female urinary microbiota

lower urinary tract symptoms

urine

bacterial DNA

bacterial isolates

benign prostatic hyperplasia

Enhanced Quantitative Urine Culture

Mass Spectrometry

overactive bladder