E-Posters-10101

10101_Medel

Pdf Summary

This pilot study aimed to evaluate the safety and efficacy of using porcine small intestinal submucosa (SIS) sling in women who had undergone pelvic radiotherapy for the treatment of stress urinary incontinence (SUI). Between August 2015 and August 2016, eight patients with a history of pelvic radiotherapy and SUI underwent a multichannel urodynamic study and transobturator installation of midurethral biological material. Objective and subjective parameters were evaluated before and 6 months after surgery. The results were compared using the paired Wilcoxon test. The study found that there were no complications during the installation or postoperative period. At six months, 87.5% of the patients did not experience stress urinary leakage. The postoperative score using the International Consultation on Incontinence Questionnaire significantly decreased from 17.5 to 0.5 (p=0.011). <br />The study suggests that the transobturator installation of a biological mesh, such as the SIS sling, could be an effective and safe alternative for treating SUI in patients with a history of gynecological cancer and pelvic radiotherapy. However, further studies with a larger sample size are needed to confirm these results. Stress urinary incontinence is a common condition, and the midurethral sling is considered the surgical gold standard for its treatment, with a success rate of 85 to 90%. Synthetic and biological materials are commonly used for this procedure, with polypropylene being the most widely used synthetic material. However, it is not recommended for women who have undergone pelvic radiation for gynecological malignancies due to its non-absorbable nature. Porcine SIS, on the other hand, is a biological material that stimulates the body's natural processes of angiogenesis, epithelial growth, and extracellular matrix organization. The authors recommend further research to expand on these promising results.

Keywords

pilot study

porcine small intestinal submucosa

SIS sling

pelvic radiotherapy

stress urinary incontinence

urodynamic study

biological mesh

gynecological cancer

synthetic material

pelvic radiation