E-Posters-10117

10117_Dutta
Pdf Summary
This study aimed to determine the incidence of lower urinary tract symptoms (LUTS) in pelvic cancer patients following treatment, specifically looking at the impact of radiation therapy. A retrospective cohort study was conducted, reviewing the medical records of gynecologic oncology patients treated between 2010 and 2015. The study included 136 patients who received radiation and/or surgery and 96 patients who received chemotherapy and/or surgery without radiation. <br /><br />The average age of the cohort was 54.97 years, with an average parity of 2.62 and a mean body mass index (BMI) of 28.98. The majority of patients were diagnosed with cervical cancer (37%), followed by endometrial cancer (26.2%) and ovarian cancer (22%). <br /><br />Results showed that 54.3% of patients reported at least one LUTS in the follow-up period. Exposure to radiation increased the relative risk (RR) of having LUTS by 1.47-fold. Additionally, a diagnosis of cervical cancer significantly increased the RR of having LUTS by 1.47-1.59-fold. Reporting LUTS was significantly associated with smoking status, increasing stage at diagnosis, a diagnosis of cervical cancer, and exposure to external beam radiation. <br /><br />Despite the risk of developing LUTS post-treatment, only about 50% of patients presenting for follow-up had documentation of a urological review of symptoms. The study concludes that women exposed to radiation for treatment of pelvic cancers are at an increased risk of experiencing bothersome LUTS. <br /><br />In summary, this study found that radiation therapy for pelvic cancer increases the risk of developing lower urinary tract symptoms. The incidence of LUTS was higher in patients with a diagnosis of cervical cancer compared to endometrial and ovarian cancers. It is recommended that further prospective studies be conducted to understand the evolution and impact of these symptoms on the quality of life of pelvic cancer survivors.
Keywords
lower urinary tract symptoms
LUTS
pelvic cancer
radiation therapy
retrospective cohort study
gynecologic oncology
chemotherapy
surgery
cervical cancer
endometrial cancer