E-Posters-10149_Glass Clark

10149_Glass Clark
Pdf Summary
A pilot study was conducted to evaluate a non-invasive method to characterize bladder geometry for overactive bladder (OAB). The study aimed to determine if bladders in women with OAB fill uniformly and to identify any differences in strain patterns. Fourteen female patients with high urgency OAB were enrolled in the study and underwent extended urodynamic testing with concurrent 3D ultrasound. Images were acquired every 60 seconds during bladder filling, and diameters were measured in the lateral, anterior-posterior, and cranio-caudal directions.<br /><br />The results showed that depth was significantly different than width and height at the beginning of the fill, but only different than width at 100% capacity. The cranio-caudal direction (height) showed the greatest change in diameter across the fill, indicating the most exaggerated strain compared to width and depth. Furthermore, two subjects showed less strain in the height direction compared to the mean strain of the group.<br /><br />The conclusions of the study were that the typical overactive bladder does not fill uniformly, with the most significant shape change occurring in the cranio-caudal dimension during urodynamic filling. The diameter strains of two participants did not follow the average pattern of the group, suggesting a different shape-mediated OAB.<br /><br />Further research involving non-OAB controls is needed to fully understand and characterize shape-mediated bladder physiology. The study was supported by NIH, VCU Presidential Research Quest Fund, and VCU Dean’s Undergraduate Research Initiative.<br /><br />In summary, this pilot study demonstrated that bladders in women with overactive bladder do not fill uniformly, and the cranio-caudal dimension undergoes the most significant shape change during filling. Two participants showed different strain patterns, indicating a potential subtype of OAB. Further research is needed to fully understand and characterize these differences.
Keywords
pilot study
non-invasive method
bladder geometry
overactive bladder
strain patterns
urodynamic testing
3D ultrasound
diameters
cranio-caudal direction
bladder filling