E-Posters-10169

10169_Li

Pdf Summary

The study titled "Does Gabapentin Reduce Opioid Use Postoperatively? (‘GROUP Study’): A randomized control trial in women undergoing reconstructive pelvic surgery" aimed to determine the effect of pre-operative gabapentin on post-operative pain control in women undergoing vaginal hysterectomy with pelvic floor reconstructive surgeries. Gabapentin is an antiepileptic drug with anti-nociceptive activity that has been shown to reduce post-operative pain and opioid requirements in previous studies.<br /><br />The study included women aged 18 and older who were undergoing symptomatic prolapse requiring hysterectomy with pelvic reconstructive surgeries. Exclusion criteria included patients already on gabapentin or with contraindications or allergies to the drug. The patients were randomized into two groups – one group received gabapentin and the other received a placebo.<br /><br />The study found no significant difference in post-operative opioid use between the two groups. Additionally, no significant adverse events or side effects of gabapentin were reported in either group. The study did have some limitations, including the use of lower doses of gabapentin compared to other studies and the exclusion of other pelvic reconstructive procedures.<br /><br />In conclusion, this study suggests that a single pre-operative dose of gabapentin did not reduce post-operative opioid use in women undergoing vaginal hysterectomy with additional pelvic floor repair. However, further research with higher doses of gabapentin and inclusion of other pelvic reconstructive procedures is necessary to confirm these findings.

Keywords

Gabapentin

opioid use

postoperative pain control

reconstructive pelvic surgery

vaginal hysterectomy

pelvic floor reconstructive surgeries

antiepileptic drug

anti-nociceptive activity

randomized control trial

symptomatic prolapse