E-Posters-10176

10176_Minassian

Pdf Summary

This study aimed to determine if remission and recurrence rates of urinary incontinence (UI) subtypes support a disease progression model. The study used data from the GLOBE-UI study, including women with stress UI (SUI), urgency UI (UUI), and mixed UI (MUI) at baseline. Remission was defined as a 6-month period without UI symptoms, and recurrence occurred when symptoms returned after remission.<br /><br />The results showed that the remission rates were 52% for SUI, 39% for UUI, and 24% for MUI. The adjusted hazard ratio (HR) for remission of SUI and UUI was significantly higher than MUI. On the other hand, the adjusted HR for recurrence of SUI was significantly lower than MUI, while the HR for UUI and MUI recurrence were similar.<br /><br />Women with SUI or UUI who remitted had fewer episodes of UI and lower Sandvik severity scores compared to women with MUI. In contrast, persistent MUI and UUI were associated with more frequent UI episodes and higher Sandvik severity scores than SUI.<br /><br />Based on these findings, the authors concluded that symptom severity is associated with the persistence of UI symptoms, where persistent MUI may represent a later stage of UI disease, possibly preceded by remitting and recurring SUI and UUI.<br /><br />In summary, this study found that different UI subtypes have varying rates of remission and recurrence, with SUI and UUI having higher remission rates than MUI. The severity of symptoms was also found to differ among subtypes, with persistent MUI and UUI being associated with more severe symptoms. These findings support the idea that UI may progress from SUI to UUI and eventually to MUI.

Keywords

urinary incontinence

UI subtypes

disease progression model

GLOBE-UI study

remission rates

recurrence rates

symptom severity

persistent MUI

Sandvik severity scores