E-Posters-10190

10190_Minassian

Pdf Summary

Researchers conducted a genome-wide association study to identify genetic variants associated with urinary incontinence (UI) and fecal incontinence (FI) in women. They analyzed data from participants of the Nurses' Health Study I (NHS) and II (NHSII), who provided information on UI and FI every two years. Genome-wide single nucleotide polymorphism (SNP) data was generated from a portion of the study participants. The researchers analyzed the data using a genome-wide association study, adjusting for principal components. They identified 7 SNPs significantly associated with UI located in two loci, chromosome 8q23.3 and 1p32.2. For FI, no SNP reached genome-wide significance, but 4 SNPs had a p-value less than 10-6. The study provides evidence of a genetic predisposition for UI and suggests that understanding genetic factors may lead to improved prevention and treatment options. UI and FI are common conditions in women that negatively impact quality of life, and their pathogenesis is poorly understood. In addition to known health and lifestyle factors, genetics may play a role in the development of UI and FI. While the study has limitations in detecting associations for less common variants, the significant findings highlight the importance of genetic factors in UI and FI and provide a basis for further research in this area.

Keywords

genome-wide association study

urinary incontinence

fecal incontinence

women

Nurses' Health Study

single nucleotide polymorphism

SNP data

genetic variants

chromosome 8q23.3

1p32.2