E-Posters-10200

10200_Wasenda

Pdf Summary

The study aimed to measure the changes in maximum urethral closure pressures (MUCPs) after urethral bulking injection and compare them to the changes after midurethral sling (MUS) placement using high resolution manometry (HRM). The primary objective was to investigate the effects of urethral bulking on urethral pressure profiles at rest and during dynamic conditions. The secondary objectives were to compare MUCP changes after urethral bulking to those after MUS and to compare changes in functional urethral length (FUL) before and after urethral bulking/MUS placement. The hypothesis was that resting and dynamic MUCPs would increase after urethral bulking injection and that changes in MUCPs would be less with urethral bulking than after MUS. However, the results showed that neither bulking nor MUS significantly affected MUCPs at rest. Under dynamic conditions, there were small increases in MUCP after urethral bulking compared to MUS, but these increases were not clinically or statistically significant. FUL increased by 0.5 cm after urethral bulking but decreased after MUS placement. The amount of bulking injection administered did not affect MUCP changes. Overall, the study concluded that the mechanism of continence after urethral bulking differs from MUS, with MUS providing a backboard to counteract increases in intraabdominal pressure and producing marked increases in MUCP, while bulking may rely on increasing FUL. The study used fast-response HRM with the ability to measure urethral pressures along its length without withdrawal as a strength, but the small sample size was a limitation.

Keywords

urethral bulking injection

midurethral sling placement

high resolution manometry

maximum urethral closure pressures

MUCPs

functional urethral length

resting urethral pressure profiles

dynamic urethral pressure profiles

intraabdominal pressure

fast-response HRM