E-Posters-10201

10201_Chai

Pdf Summary

Researchers at Yale School of Medicine have developed a mouse model that recapitulates the symptoms of overactive bladder (OAB) by overexpressing the enzyme ornithine decarboxylase (ODC) in the bladder urothelium. The study aimed to investigate whether urothelial-specific overexpression of ODC would reproduce the voiding phenotype of OAB and involve an abnormal inflammatory response. The researchers created a transgenic mouse line with urothelium-specific overexpression of ODC and compared it to wildtype and negative littermates. The study found that the uODC-OE+ mice exhibited an increased number of urine spots, which mimicked the OAB phenotype. Additionally, the urine specimens from uODC-OE+ mice showed elevated levels of certain cytokines associated with dysfunctional innate immunity. The results suggest that overexpression of ODC in the bladder urothelium can reproduce the symptoms of OAB and may involve an aberrant immune response. This mouse model provides a valuable tool for studying OAB and identifying potential targets for future treatment.

Keywords

Yale School of Medicine

mouse model

overactive bladder

ornithine decarboxylase

bladder urothelium

urothelial-specific overexpression

voiding phenotype

abnormal inflammatory response

transgenic mouse line

urine spots