E-Posters-10204

10204_Price

Pdf Summary

A study was conducted to compare different diagnostic thresholds for urinary tract infection (UTI) in urogynecologic patients. The objective was to determine the proportion of patients with at least one uropathogen detected using four diagnostic thresholds and assess symptom resolution after treatment. 75 urogynecologic patients who reported UTI symptoms were enrolled in the study. Standard urine cultures and an enhanced quantitative urine culture (EQUC) protocol were used to assess urine samples. The diagnostic thresholds for uropathogen detection were ≥105, ≥104, and ≥103 CFU/ml by standard urine culture, and the presence of any uropathogen detected by EQUC. The results showed that EQUC detected 23 known and emerging uropathogens in almost all patients. The proportion of patients with at least one uropathogen decreased as the diagnostic threshold increased. At the ≥105 CFU/mL threshold, most patients with uropathogens had Gram-negative bacteria. However, when using the "any" threshold, 62% of patients had polymicrobial or Gram-positive uropathogens. Many treated patients reported symptom resolution within one week, while many untreated patients with uropathogens present below ≥105 CFU/mL reported persistent UTI symptoms. The study concluded that uropathogens are commonly present in urogynecologic patients who self-report UTI. Patients with polymicrobial or Gram-positive infections are less likely to be diagnosed and treated for UTI. The study suggests that the diagnostic threshold for UTI needs to be updated to improve diagnosis and treatment for patients.

Keywords

diagnostic thresholds

urinary tract infection

urogynecologic patients

uropathogen detection

symptom resolution

treatment

urine cultures

EQUC

Gram-negative bacteria

polymicrobial uropathogens