E-Posters-10215

10215_Alam

Pdf Summary

This study aimed to compare the rates and severity of complications in patients with hereditary disorders of connective tissue (HDCT) undergoing surgery for pelvic organ prolapse (POP) and stress urinary incontinence (SUI) compared to patients without HDCT. The study also evaluated pre- and postoperative symptoms, support, and recurrence rates in both groups. A total of 59 patients with HDCT and 118 patients without HDCT were analyzed. The majority of HDCTs were Ehlers-Danlos syndrome (EDS). Patients with HDCT had higher rates of perioperative complications (34% vs 18%) and readmissions (14% vs 3%) compared to those without HDCT. However, there were similar rates of specific complications such as urinary retention, hematoma, ileus/bowel obstruction, fever, wound infection/separation, and reoperation between the two groups. Patients with HDCT also had slightly higher blood loss (139ml vs 129ml). There was no difference in complications graded by the Clavien-Dindo system. There were no significant differences in POP or SUI recurrence, retreatment, or other pre- and postoperative symptoms and anatomic outcomes between the two groups. The study concluded that patients with HDCT have higher overall complication rates but similar outcomes following surgery for POP and SUI compared to patients without HDCT. This information can be useful for counseling patients with HDCT who are undergoing gynecologic and non-gynecologic surgery. The study has some limitations as it is retrospective in nature.

Keywords

hereditary disorders of connective tissue

surgery

pelvic organ prolapse

stress urinary incontinence

complications

Ehlers-Danlos syndrome

perioperative complications

readmissions

blood loss

anatomic outcomes