E-Posters-10244

10244_Tennyson
Pdf Summary
In this study, the researchers aimed to characterize the T cell response in the context of the foreign body response to vaginal mesh. T cells were found to be almost as prevalent as macrophages in the cellular infiltrate surrounding the mesh fibers. T lymphocytes are known to play a role in tissue fibrosis. The researchers observed that T cells were present in a specific distribution area around the vaginal mesh fibers removed from women with complications.<br /><br />The complexity of the T cell response to mesh complications is not well understood, but it may be a central pathway with different clinical presentations. Further research is needed to understand how T lymphocytes influence the response to vaginal mesh and the clinical outcomes. <br /><br />The study also compared T cell subtypes between mesh-exposed women and women experiencing pain. The results showed significant differences in T cell subtypes between these groups. The study also found that the presence of T cells was positively correlated with connective tissue growth factor (CTGF), a marker of tissue fibrosis. The researchers observed teardrop-shaped fibromas encapsulating mesh fibers, with T cells localized within the tip of this configuration, away from the mesh-tissue interface.<br /><br />In addition to T cells, the study also examined the presence of macrophages, specifically M1 proinflammatory macrophages. They were predominantly localized to the mesh-tissue interface. The study also found higher levels of CTGF in mesh vagina explants compared to control tissue.<br /><br />In conclusion, this study provides further characterization of the T cell response to vaginal mesh in women with complications. It highlights the importance of studying T lymphocytes in understanding mesh biology and clinical outcomes. The findings suggest a potential role for T cells in the pathogenesis of mesh complications and tissue fibrosis.
Keywords
T cell response
vaginal mesh
macrophages
cellular infiltrate
tissue fibrosis
T cell subtypes
pain
connective tissue growth factor
mesh-tissue interface
clinical outcomes