E-Posters-10266

10266_Hung
Pdf Summary
The study found that different species of Lactobacillus, a type of bacteria commonly found in the vagina, can inhibit the growth of E. coli, a bacteria responsible for most urinary tract infections (UTIs). Specifically, Lactobacillus strains that produce hydrogen peroxide (H2O2) were associated with decreased E. coli growth. Lactic acid, produced by Lactobacillus, was also found to downregulate factors that allow E. coli to adhere to surfaces.<br /><br />Lactobacillus probiotics have previously been shown to reduce the recurrence of UTIs, but the precise mechanism behind this effect is not well understood. This study aimed to determine whether different strains of Lactobacillus crispatus, a common species found in the vagina, produce substances that equally inhibit the growth of E. coli. The study used spent broth cultures of Lactobacillus, which were co-cultured with E. coli. The results showed that all Lactobacillus strains, excluding L. johnsonii, significantly inhibited E. coli growth compared to control groups.<br /><br />The study also found that both H2O2-producing and non-producing Lactobacillus species had a negative effect on E. coli growth. Additionally, different strains of L. crispatus showed similar inhibition of E. coli growth, regardless of whether they were clinical or laboratory strains. The response of clinical E. coli strains to Lactobacillus products was similar to that of laboratory strains, although not statistically significant. <br /><br />The findings suggest that Lactobacillus, particularly H2O2-producing strains and substances produced by lactobacilli, could be used as potential therapeutic or preventive agents against UTIs. However, further research is needed to isolate these substances and determine their exact mechanism of action. The study highlights the potential of using L. crispatus probiotics to prevent UTIs, but notes that colonization must occur for them to be effective.
Keywords
Lactobacillus
bacteria
vagina
E. coli
urinary tract infections
UTIs
hydrogen peroxide
lactic acid
probiotics
L. crispatus