E-Posters-Detection of Group B Streptococcus (S. agalactiae) in Various Genitourinary Sample Techniques Varies Daily

Detection of Group B Streptococcus (S. agalactiae) in Various Genitourinary Sample Techniques Varies Daily - Birte J Wolff, MD

Back to course

Pdf Summary

This document discusses a study that aimed to determine the daily fluctuations of Group B Streptococcus (GBS) in the microbiome of the genital tract of young, healthy, non-pregnant women. It also compared the detection rate of GBS among three different specimen sources: voided urine, peri-urethral swab, and rectovaginal swab. The study found that the detection of GBS varied across these different specimen types and that a single rectovaginal swab may not accurately identify women as GBS negative. Performing multiple rectovaginal swabs may be necessary to increase the detection rate.<br /><br />The study was a subanalysis of the data collected in a larger study on oral probiotics and the female urinary microbiome. The inclusion criteria for participants were premenopausal, healthy, at least 18 years old, and able to provide daily specimen collections and read/speak English. The specimens collected included daily midstream voided urine and peri-urethral swabs, as well as weekly rectovaginal swabs, over a three-month period. The primary outcome measurement was bacterial culture using GBS colony forming units/ml.<br /><br />The study found that the presence of GBS was most frequently detected in the rectovaginal swab, but the detection rates fluctuated over time. The presence of GBS in the birth canal is important during prenatal care as GBS sepsis in newborns can be life-threatening. However, the incidence of GBS early-onset sepsis in newborns remains relatively low. It remains unclear how the presence of GBS fluctuates in the mother's microbiome.<br /><br />The document includes tables showing the incidence of GBS detection on different specimen types and the associations between GBS detection and various lifestyle factors. It concludes by stating that four out of seven participants were found to have GBS in at least one specimen during the study, highlighting the importance of monitoring GBS in non-pregnant women.

Keywords

Group B Streptococcus

microbiome

genital tract

young women

non-pregnant

voided urine

peri-urethral swab

rectovaginal swab

detection rate

multiple rectovaginal swabs