E-Posters-Do Cytokine Concentrations in OAB Patients Correspond with Urodynamic Results?

Do Cytokine Concentrations in OAB Patients Correspond with Urodynamic Results? - George Araklitis, MD

Pdf Summary

The purpose of this study was to determine if there is a correlation between cytokine concentrations in bladder biopsies and urodynamic results in patients with overactive bladder (OAB). Cytokines are regulatory molecules that play a role in immune responses and inflammation. Previous evidence has suggested that inflammation is involved in the development of OAB. The cytokines TNFalpha and CCL2 have been found to be upregulated in OAB.<br /><br />The study involved a retrospective review of data from a pilot study. Two groups were identified: one with confirmed detrusor overactivity (DO) during urodynamics, and a control group that underwent cystoscopy for other reasons. Urodynamic parameters were compared with cytokine concentrations found in bladder biopsies, as well as King's Health Questionnaire (KHQ) scores.<br /><br />The results of the study showed no significant correlation between urodynamic data or KHQ scores and cytokine concentrations in patients with DO. This finding confirms a previous study that also found no correlation.<br /><br />The study concluded that while biomarkers such as cytokines may be helpful in diagnosing DO in the future, urodynamics are still necessary and cannot be replaced. The demographics and urodynamic data were not significantly different between the control group and the DO group, except for a slight difference in the first sensation during urodynamics.<br /><br />In summary, this study found no biologically significant correlation between cytokine concentrations and urodynamic results in patients with DO. This suggests that urodynamics remains an important objective assessment for diagnosing OAB, and further research is needed to explore the potential of cytokine biomarkers.

Keywords

correlation

cytokine concentrations

bladder biopsies

urodynamic results

overactive bladder

inflammation

TNFalpha

CCL2

detrusor overactivity

King's Health Questionnaire