E-Posters-Effect of a Fibrinogen-coated Collagen Patch on Connective Tissue Formation

Effect of a Fibrinogen-coated Collagen Patch on Connective Tissue Formation - Aiste Ugianskiene, MD

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A study was conducted on pigs to investigate the effect of a fibrin-collagen coated patch (FCP) on connective tissue formation. The FCP was applied to the abdominal fascia during surgery and the animals were sacrificed five weeks later for analysis.<br /><br />The results showed that the FCP was able to induce focal subserosal inflammation and fibrosis. This indicates that the FCP may contribute to connective tissue formation and potentially reduce the risk of recurrence in women undergoing surgery for pelvic organ prolapse.<br /><br />The study was conducted by researchers from the Department of Obstetrics and Gynecology at Aalborg University Hospital in Denmark, along with experts from the Institute of Pathology, Department of Surgery, and Department of Thoracic Surgery, also at Aalborg University Hospital, as well as the Department of Upper GI Surgery at the Royal Infirmary Of Edinburgh in the UK.<br /><br />This study suggests that the FCP could be used to increase the strength of fascial tissue following surgical repair of pelvic organ prolapse. The FCP could also be used for other purposes such as surgical hemostasis, tissue sealing, supporting sutures, preventing adhesions and erosions, protecting nerves, and occluding structures like bronchioles, lymph vessels, or bile ducts.<br /><br />Overall, the results of this study provide promising evidence for the potential benefits of using a fibrin-collagen coated patch in surgical interventions. Further research is needed to fully understand its efficacy and safety in clinical settings.

Keywords

fibrin-collagen coated patch

connective tissue formation

abdominal fascia

subserosal inflammation

fibrosis

pelvic organ prolapse

surgery

recurrence

fascial tissue

efficacy