E-Posters-Intravesical Antibiotic Administration in the Treatment of Recurrent UTIs: Promising Results from a Case Series

Intravesical Antibiotic Administration in the Treatment of Recurrent UTIs: Promising Results from a Case Series - Sofiya Chernyak, MD

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This study aimed to assess the effectiveness of intravesical antibiotic instillations in the treatment of recurrent urinary tract infections (UTIs). The research team performed a chart review to select patients who had experienced two or more UTIs within a six-month period. The instillations were administered by trained nursing staff using either gentamycin or tobramycin, following bladder irrigation with sterile water. The researchers compared the rates of UTIs and the total number of pathogens before and after instillations through a chart review.<br /><br />The study included 12 postmenopausal women with a mean age of 80.3 years. All patients had used vaginal estrogen for at least six months prior to starting the instillations. On average, patients received 8.4 instillations during the treatment period, with 11 patients receiving gentamycin and one patient receiving tobramycin. The results showed significant improvements after instillations. The average rate of UTIs decreased by more than 50%, from a median of 2.5 infections to 1.5 infections. The total number of pathogen types also decreased by more than 50%, from a median of 2.5 to 1.5. Additionally, there was a 50% decrease in bacterial antibiotic resistance. No side effects were reported during the instillations.<br /><br />The study concludes that intravesical antibiotics are a safe and effective method for treating recurrent UTIs in postmenopausal women. Further research is needed to determine the optimal approach to administration and identify the best candidates for this therapy. Overall, this case series suggests promising results for the use of intravesical antibiotics in the treatment of recurrent UTIs, particularly in postmenopausal women.

Keywords

intravesical antibiotic instillations

recurrent urinary tract infections

effectiveness

chart review

gentamycin

tobramycin

bladder irrigation

postmenopausal women

vaginal estrogen

bacterial antibiotic resistance