E-Posters-Pathophysiology of Ulceration in Women Using a Pessary: An Experimental Approach

Pathophysiology of Ulceration in Women Using a Pessary: An Experimental Approach - Marie-Elisabeth Bouchard, MD

Pdf Summary

The study examined the pathophysiology of ulcerations in women using pessary for pelvic organ prolapse. The primary objective was to determine if there was a significant change in vaginal pH in patients with erosions, while the secondary objective was to analyze the variation in vaginal microbiota in women with erosions. <br /><br />The results showed that vaginal pH was significantly higher in patients with ulceration, suggesting that an increase in pH may change the properties of mucosal proteins, leading to increased friction. There was no significant difference in pH between healthy and ulcerated areas. The study also found that patients with erosions had a change in vaginal flora, with a greater bacterial diversity and a decrease in lactobacilli. <br /><br />Based on these findings, the study concluded that women with vaginal erosions have a significantly higher vaginal pH compared to control women. The microbiota of women with erosions also showed significant changes, including increased bacterial diversity and the presence of certain bacteria. The study suggests that future research should focus on therapeutic options that aim to decrease vaginal pH or restore a bacterial flora with a predominance of lactobacilli. <br /><br />This study provides valuable insights into the pathophysiology of ulcerations in women using pessary for pelvic organ prolapse. Understanding the factors that contribute to erosions can help improve the management and treatment of this condition, ensuring the effectiveness of pessary as a non-invasive and inexpensive treatment option for pelvic organ prolapse.

Keywords

ulcerations

pessary

pelvic organ prolapse

vaginal pH

erosions

vaginal microbiota

friction

bacterial diversity

lactobacilli

management