E-Posters-Real-world Performance of onabotulinumtoxin A (BOTOX) and Sacral Nueromodulation (SNM)

Real-world Performance of onabotulinumtoxin A (BOTOX) and Sacral Nueromodulation (SNM) - Dominique Thomas, BS

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The study aimed to assess the real-world performance of Onabotulinumtoxin A (BOTOX) and Sacral Neuromodulation (SNM) for the treatment of urinary urge incontinence. The researchers analyzed data from 2012 to 2015 from the Statewide Planning and Research Cooperative System in New York. They identified patients who underwent BOTOX or SNM treatment and any associated complications within 30 days.<br /><br />A total of 2,854 patients underwent BOTOX or SNM between 2008 and 2015. The majority of patients were female (78.5%) and had a mean age of 61.1 years. The primary indication for treatment was wet overactive bladder. The most common complications were related to emergency room visits and urinary retention.<br /><br />The study found that BOTOX was a safe and effective treatment option for patients with overactive bladder symptoms compared to SNM. When comparing the two treatments, BOTOX had a lower rate of complications such as urinary tract infection, hematuria, and urinary retention. However, SNM had a 10% malfunction rate requiring reintervention within one year.<br /><br />The researchers also noted that only one-third of patients who received BOTOX returned for reinjection, and there was a high rate of emergency room visits within 30 days. They suggest that a registry is urgently needed to guide the safe utilization of these third-line therapies.<br /><br />In conclusion, this study highlights the real-world performance of BOTOX and SNM for urinary urge incontinence. BOTOX was found to be a safe and effective treatment option compared to SNM, although there were still complications associated with both treatments. The findings emphasize the need for further research and a registry to ensure the safe use of these therapies.

Keywords

Onabotulinumtoxin A

BOTOX

Sacral Neuromodulation

urinary urge incontinence

real-world performance

complications

emergency room visits

urinary retention

overactive bladder symptoms

registry