E-Posters-Targeting the Subtrigonal Zone as a Potential Area to Treat Overactive Bladder (OAB): An MRI Study in Females

Targeting the Subtrigonal Zone as a Potential Area to Treat Overactive Bladder (OAB): An MRI Study in Females - Gamal M. Ghoniem, MD, FACS

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A study was conducted to evaluate the potential use of the subtrigonal zone as a target for treating overactive bladder (OAB) in females. The study included 175 subjects and measured various anatomical characteristics using MRI imaging. The results showed that subjects under the age of 45 had a thicker anterior vaginal wall and longer distance from vaginal epithelium to bladder urothelium compared to subjects over the age of 55. Obese subjects had a thicker anterior wall compared to those with a normal BMI. The presence of fibroids was associated with a smaller urethral width. Additionally, Asian and African-American subjects had thicker bladder walls than Caucasians. No significant differences in the subtrigonal space were observed in other conditions. The study aimed to provide a better understanding of the anatomical characteristics and variations in the subtrigonal area to aid in the development of targeted therapeutic approaches for OAB treatment in women. Previous research has shown the subtrigonal region to be richly innervated, and selective therapies have been tested to treat OAB. MRI imaging is increasingly being used to evaluate the female pelvis due to its high-resolution capabilities. This study contributes to the knowledge and potential advancements in targeted OAB therapies.

Keywords

subtrigonal zone

overactive bladder

anatomical characteristics

MRI imaging

anterior vaginal wall

obese subjects

fibroids

urethral width

therapeutic approaches

OAB treatment