E-Posters-The Immuno-Histochemical Analysis on Polypropylene Mesh: Does Mesh Size Make a Difference?

The Immuno-Histochemical Analysis on Polypropylene Mesh: Does Mesh Size Make a Difference? - Tsia Shu Lo, MD

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A study was conducted to investigate the impact of mesh size on the immuno-histochemical reaction in relation to mesh-related complications in clinical practice. The study used 54 female Sprague Dawley rats, aged 12-15 weeks and weighing 302.1 ± 25.1g. Various measurements and analyses were performed on the rats at different time points. <br /><br />The study found that larger mesh implants had higher levels of inflammatory mediators, which decreased over time from Day 7 to Day 30. The size of the mesh was directly proportional to the inflammatory reaction, resulting in delayed tissue remodeling and angiogenesis. <br /><br />Specifically, the analysis showed that IL-1 and TNF-α had higher densities in larger mesh implants on both Day 7 and Day 30. The same trend was observed for MMP-2, with higher densities in larger mesh implants on both time points, but with lower densities on Day 30 compared to Day 7. The analysis of NGF indicated that larger mesh implants had higher inflammatory reactions on Day 7, but by Day 30, the groups were similar to the control group. CD-31 densities were higher in larger mesh implants on Day 7, but decreased on Day 30 while still remaining higher than smaller mesh implants. <br /><br />Overall, this study suggests that the size of the mesh implant plays a significant role in the inflammatory response and subsequent complications. Understanding the immuno-histochemical reaction to mesh size could help explain the occurrence of mesh-related issues.

Keywords

mesh size

immuno-histochemical reaction

mesh-related complications

clinical practice

inflammatory mediators

tissue remodeling

angiogenesis

IL-1

TNF-α

MMP-2