E-Posters-The Impact of Bladder Hydrodistention on Gene Expression in Biopsy Tissue from IC/BPS Patients

The Impact of Bladder Hydrodistention on Gene Expression in Biopsy Tissue from IC/BPS Patients - Jeffrey S. Schachar, MD

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This study aimed to determine if bladder hydrodistention (HOD) has an impact on gene expression in patients with interstitial cystitis/bladder pain syndrome (IC/BPS). Biopsies were collected from 10 IC/BPS patients before and after HOD, as well as from 4 non-IC/BPS controls. Whole genome microarrays were used to analyze gene expression differences. The results showed a clear and statistically significant separation between gene expression profiles in control and IC/BPS samples. However, there were no significant differences in gene expression between IC/BPS samples before and after HOD. <br /><br />These findings suggest that gene expression in IC/BPS samples is different from non-IC/BPS controls, and the hydrodistention procedure itself does not significantly impact gene expression. Therefore, comparing gene expression in bladder tissues that have undergone HOD to control samples that have not undergone HOD is a valid approach. <br /><br />Overall, this study provides support for using gene expression analysis to compare IC/BPS patients to non-IC/BPS controls and highlights that HOD does not significantly alter gene expression in IC/BPS patients.

Keywords

bladder hydrodistention

gene expression

interstitial cystitis

bladder pain syndrome

biopsies

whole genome microarrays

gene expression profiles

IC/BPS samples

non-IC/BPS controls

hydrodistention procedure