E-Posters-Urinary Choline Levels are Decreased in Women with Urgency Urinary Incontinence

Urinary Choline Levels are Decreased in Women with Urgency Urinary Incontinence - David Sheyn, MD

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The study aimed to determine if levels of choline, the precursor of acetylcholine, are different in women with urgency incontinence compared to healthy controls. Urine samples were collected from 103 women, with 33 being excluded due to various reasons. The remaining 70 participants were divided into two groups: those with urgency incontinence and those without. The group with urgency incontinence had higher age, higher likelihood of being obese, greater apical descent, higher likelihood of being post-menopausal, and higher likelihood of having stress incontinence. Choline levels were found to be 34.8% lower in women with urgency incontinence compared to the control group. Choline levels also showed a weak negative correlation with urgency incontinence scores. Logistic regression analysis revealed that decreasing choline levels, age, and BMI were significantly associated with urgency incontinence. The study concluded that choline levels are significantly decreased in women with urgency incontinence and lower levels are associated with higher urgency incontinence scores. The findings suggest a potential role for choline in the development or progression of urgency incontinence.

Keywords

choline

acetylcholine

women

urgency incontinence

healthy controls

age

obese

apical descent

post-menopausal

stress incontinence