E-Posters-Using Nocturnal Urine Production Rate in Women to Define Nocturnal Polyuria

Using Nocturnal Urine Production Rate in Women to Define Nocturnal Polyuria - Ana Sofia Da Silva

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The study examined the use of nocturnal urine production rate (NUP) as a measure to define nocturnal polyuria (excessive production of urine during the main sleep period) in women. The researchers collected data from 500 female patients attending an outpatient urogynaecology clinic who completed a 3-day bladder diary. The mean age of the patients was 57.2, and the mean NUP was 66.7 mL/hr. There was no significant correlation between NUP and age. However, a diagnosis of 24-hour polyuria (excessive urine production over a 24-hour period) was significantly associated with abnormal NUP.<br /><br />The study found that the use of NUP to classify nocturnal polyuria may be helpful, but the threshold of 90 mL/hr may need to be refined for different populations. It was also noted that using NUP alone may not differentiate between patients with pure nocturnal polyuria and those with 24-hour polyuria. Other definitions that include 24-hour voided volume may be more useful in such cases. The study did not find a significant effect of age on nocturnal polyuria, questioning the utility of using age-specific cutoffs for defining nocturnal polyuria in patients over 65.<br /><br />The study had a weakness in that it did not control for weight or fluid intake. Further research is needed to establish a standardized definition for nocturnal polyuria. The results indicate that NUP is associated with increased episodes of nocturia but only moderately discriminates nocturnal polyuria. At a cutoff of 90 mL/hr, 46% of patients with two or more nocturnal voids were correctly classified as having nocturnal polyuria, with a false positive rate of 15%.<br /><br />The study had various author disclosures, including commercial affiliations with pharmaceutical and medical device companies.<br /><br />In summary, the study suggests using NUP as a measure for defining nocturnal polyuria in women but highlights the need for further research to establish standardized definitions and refine cutoffs for different populations.

Keywords

nocturnal urine production rate

NUP

nocturnal polyuria

excessive urine production

main sleep period

bladder diary

24-hour polyuria

age-specific cutoffs

nocturia

false positive rate