PFD Week 2018-Concurrent Session #1: Basic Science

Video Transcription

Video Summary

The first presenter discussed the use of interleukin-4 (IL-4) as a potential treatment for mesh-related complications. The presenter explained that IL-4 is a cytokine that can induce a transition from a pro-inflammatory M1 macrophage response to an anti-inflammatory M2 response. The presenter described a study in which IL-4 was tagged with a fluorescent marker and coated onto implantable mesh. Using in vivo imaging, the researchers observed the release of IL-4 from the mesh over time. The goal of the study is to find a release pattern that mimics normal wound healing and reduces mesh-related complications.<br /><br />The second presenter discussed the contractile response of vaginal tissue under various circumferential and axial loads. The presenter explained that the vagina is sensitive to circumferential loads, such as pressure, which can affect the magnitude of contraction. However, length and axial force did not significantly impact the contraction. The presenter concluded that the two muscle cells of the vagina are more aligned in the circumferential direction and are sensitive to circumferential loads.<br /><br />The third presenter compared the host immune and extracellular matrix (ECM) responses to polypropylene and polycarbonate urethane (PCU) mesh in a rat model. The presenter explained that polypropylene mesh is currently used in prolapse repair, but can elicit a persistent inflammatory response. PCU mesh, on the other hand, has similar mechanical properties to the vagina and may be a promising alternative. The researchers found that both polypropylene and PCU mesh elicited minimal inflammatory responses, and PCU did not have a more robust response than polypropylene. The presenter concluded that PCU is a promising material for prolapse mesh.<br /><br />Overall, these presentations highlighted the potential use of IL-4 as a treatment for mesh-related complications, the contractile response of vaginal tissue under different loads, and the comparison of polypropylene and PCU mesh in terms of host responses.

Asset Subtitle

Rui Liang, MD, MSc, Aimon Iftikhar, MS, Jennifer A Bickhaus, MD, Amanda M. Artsen, MD, Katrina M Knight, PhD, Alexis L Nolfi, BS, Gabrielle L. Clark, BS, & Peter L. Rosenblatt, MD, FACOG

Meta Tag

Category Complications

Category Education

Category Urinary Incontinence

Keywords

interleukin-4

mesh-related complications

implantable mesh

vaginal tissue

circumferential loads

polypropylene mesh

polycarbonate urethane mesh

prolapse repair

host immune response